Nottingham Forest reached the FA Cup quarter-finals as they beat fellow Premier League club Ipswich Town on penalties after the City Ground clash ended 1-1 after extra time on Monday.
Manchester United languish 14th in the standings on 19 points, their worst placing to end a calendar year since they were 15th in 1989.
Norwich City winger Borja Sainz has been suspended for six matches and fined 12,000 pounds ($14,749) for spitting at an opponent.
It is the first time since 1989-90 that Manchester United have lost 10 of their first 22 games of the league season.
A summary of Tuesday's action in the Premier League.
Brazil, who are fifth in the CONMEBOL table with 18 points from 12 games, host Colombia on March 21 and visit Argentina five days later in a match that could see Neymar come up against former Barcelona and Paris St Germain teammate Lionel Messi.
Manchester City's spending of more than 180 million pounds ($223.58 million) was the second-biggest outlay ever worldwide by a club in the January transfer window.
IMAGES from the EPL matches played on Saturday.
Manchester City have now won only once in 11 games in all competitions.
'I want to make as big of an impression as I can and then just try and make the next camp. But obviously, every little kid's dream is to play in a World Cup.'
Brighton & Hove Albion and Nottingham Forest maintained unbeaten starts to the Premier League season with a topsy-turvy 2-2 draw as the visitors finished with 10 men and both managers were shown red cards in a feisty clash on Sunday.
A round-up of Saturday's action in the English Premier League.
IMAGES from the Premier League matches played on Saturday.
Manchester City thrashed West Ham United 4-1 in the Premier League on Saturday to claim their first back-to-back wins since October.
Graham Potter is in talks to replace Lopetegui, according to British media reports, and the former Chelsea and Brighton & Hove Albion manager is expected to take charge of West Ham for their FA Cup third-round game at Aston Villa on Friday.
A round-up of Saturday's fifth round action in the FA Cup
To mark World Mental Health Day, English footballer Connolly opens up about alcoholism, rehab
A summary of Saturday's action in the FA Cup third round.
Manchester City spent more than 180 million pounds ($223.58 million) -- more than the combined amount paid by the other 19 English top-flight clubs in a relatively quiet window.
IMAGES from the Premier League matches played on Saturday.
Arsenal were held to a 1-1 Premier League draw by London rivals Fulham on a grey wet Sunday at Craven Cottage as Raul Jimenez scored early for the hosts and William Saliba equalised for the visitors at the start of the second half.
Chelsea got their Premier League campaign on track after 20-year-old right back Reece James helped them to a 3-1 win at Brighton & Hove Albion with a spectacular goal on Monday.
Woeful defending led to two Brighton goals in two first-half minutes as 34-year-old Glenn Murray and Shane Duffy outsmarted United's 117 million pound ($149.21 million) back four to demonstrate why manager Jose Mourinho had sought to upgrade it.
The Premier League found a record 42 cases of COVID-19 among players and staff at various clubs over the past week.
Brighton and Hove Albion made sure of Premier League football next season with two games to spare after a Pascal Gross goal gave them a memorable 1-0 home win over Manchester United on Friday.
A round-up of Saturday's action in the English Premier League.
Liverpool climbed to the top of the Premier League table with a 2-1 victory over struggling Wolverhampton Wanderers on Saturday.
A summary of Sunday's action in the Premier League.
A brilliantly-worked goal by Ryan Christie and a Justin Kluivert penalty gave Bournemouth shock 2-0 Premier League win at home to 10-man Arsenal.
Brighton & Hove Albion scored three times in the second half to fight back from two goals down and beat Manchester City
City slumped to a fourth consecutive loss in all competitions with a 2-1 defeat at Brighton & Hove Albion in the Premier League on Saturday
Images from the English Premier League matches played on Sunday.
Arsenal's Arteta wary of old foe Villa
A summary of Saturday's action in the English Premier League.
Tracking the key moves this week in the European transfer market
Tottenham Hotspur missed the chance to move up to provisional fourth place in the Premier League after relegation-threatened Newcastle United held them to a 2-2 draw with a late equaliser from substitute Joe Willock at St James' Park on Sunday. Images from EPL matches played on Sunday.
Ben Johnson and Tomas Soucek scored second-half goals as West Ham United twice came back from a goal down to earn a 2-2 draw at home to Brighton and Hove Albion in the Premier League on Sunday.
Images from the English Premier League matches played on Sunday
A round-up of Sunday's action in the Premier League.
Brighton kept a disciplined formation, frustrating Liverpool and as the second half wore on the home side began to lose their fluency.
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